Neuroplasticity 101


What Is Neuroplasticity?

The brain creates new neural pathways and modifies existing ones in response to behavioral, environmental, and neural changes.11 This process of neuroplasticity, also known as brain plasticity, continues throughout our lives, involves many processes and is influenced by new experiences.22

Until recently, scientists believed that brain development came to a halt during adulthood. But researchers now know that our brains change constantly throughout our lives, forming new pathways to adjust to our environment and actions.33 For example, neuroplasticity allows the brain to compensate for injury and disease.44

Understanding how brain plasticity works can help us attain our own cognitive goals as well as improve the ways experts treat and support people with neurological and behavioral health problems.

How Do Our Brains Change?

Neuroplasticity would not be possible without the malleable traits of neurons. Neurons are what cause the brain to change and the entire body to function effectively.55 Neurons are the longest-living cells in our bodies and are responsible for carrying information throughout the brain and then on to the muscles and organs of the body.66

Our brains have the extraordinary capacity to change both structurally and functionally. Structural plasticity involves our brains changing its physical structure as we learn new things or form new memories. Functional plasticity is the brain’s ability to move functions from a damaged area of the brain to other undamaged areas.77

How Do Neurons Communicate?

A neuron generates electrical charges as it signals from other neurons.88 Synapses, the tiny gaps where chemicals called neurotransmitters are released to transfer information from one cell to another, must be reinforced to remain active.99 The more synaptic pathways are used, the stronger the communication between neurons.1010

As we adapt to new environments, our brains dispose of unused or unnecessary neural connections while strengthening and preserving those that are used frequently.1111 This activity is called synaptic pruning. For the brain to operate efficiently, synaptic pruning must maintain a proper balance.1212 Researchers suggest that imbalanced brain pruning could be linked to some psychiatric and neurodegenerative issues. If not enough pruning occurs, the brain remains hyperconnected, which studies observe occurs in many cases of autism.1313 Conversely, too much pruning disrupts communication between neurons, an abnormality found in Alzheimer’s disease and schizophrenia.14141515

How Do Neurons Grow and Repair Themselves?

The human brain has billions of neurons, some of which can than live more 100 years in humans.1616 Unused neurons grow weak and die through a process called apoptosis, but can be regenerated by neurogenesis, the creation of new brain cells.1717 With the support of other types of brain cells called glial, neurons can constantly repair, remodel and regenerate themselves.1818

How Can You Rewire Your Brain?

Early childhood is the most critical time for learning. Though brain plasticity happens throughout our lives, children have a greater ability to learn and retain information.1919 At birth, infants have approximately 2,500 synapses in the brain. From infancy to age 3, a child’s brain produces 15,000 synapses.2020 Throughout adolescence, neurons weaken, reducing synapses by 50%.2121

How can we build and maintain those connections that are relevant during early childhood and even later into adulthood? Neuroplasticity involves a “fire together, wire together” principle: If certain neurons keep firing at the same time, eventually they’ll develop a physical connection and become physically associated.2222 This experience-dependent plasticity means if you practice something consistently, such as meditating, exercising or learning how to play an instrument, you’re likely to alter your brain to associate the relevant parts of its structure.2323 Whether you are a child, adolescent or older adult, actions and thoughts (both positive and negative) that you repeat can form new neural pathways.

At the BrainFutures conference, Dr. Bruce Wexler, Professor Emeritus of Psychiatry and Senior Research Scientist at Yale School of Medicine, discussed the principles of neuroplasticity. Watch video below.



[1] Demarin, V., Morovic, S. & Béné, R. (2014). Neuroplasticity. Periodicum Biologorum, 116, 209-211.
[2] Ibid.

[3] Liou, S. (2010, June 26). Neuroplasticity. Huntington’s Disease Outreach Project for Education, at Stanford University. Retrieved from
[4] Ibid.
[5] National Institute of Neurological Disorders and Stroke (n.d.) Brain Basics: The Life and Death of a Neuron. Retrieved from
[6] Ibid.
[7] Oberman, L., & Pascual-Leone, A. (2013). Changes in plasticity across the lifespan: Cause of disease and target for intervention. Progress in Brain Research, 207, 91–120.
[8] Pereda, A. (2014). Electrical synapses and their functional interactions with chemical synapses. Nature Reviews Neuroscience, 15, 250–263.
[9] Sukel, K. (2011, March 15). The Synapse-A Primer. Retrieved from
[10] Ibid.
[11] Noggle, C. A., & Santos, E. (2011). Synaptic Pruning. Retrieved from
[12] Afroz, S., Parato, J., Shen, H., & Smith, S. (2016, May 02). Synaptic pruning in the female hippocampus is triggered at puberty by extrasynaptic GABAA receptors on dendritic spines. eLife, 5:e15106 doi: 10.7554/eLife.15106
[13] Ibid.
[14] Hong, S., Beja-Glasser, V. F., Nfonoyim, B. M., Frouin, A., Li, S., Ramakrishnan, S., . . . Stevens, B. (2016, May 06). Complement and microglia mediate early synapse loss in Alzheimer mouse models. Science, 352(6286), 712-716. doi:10.1126/science.aad8373
[15] Sellgren, C. M., Gracias, J., Watmuff, B., Biag, J. D., Thanos, J. M., Whittredge, P. B., . . . Perlis, R. H. (2019, February 04). Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning. Nature Neuroscience, 22, 374-385. Retrieved from
[16] Sukel, K. (2011, March 15). The Synapse-A Primer.
[17] Moskowitz, M. A., & Lo, E. H. (2003, February 01). Neurogenesis and Apoptotic Cell Death. Stroke, 34(2), 324-326. doi:10.1161/
[18] National Institute on Aging (n.d.) What Happens to the Brain in Alzheimer’s Disease? Retrieved from
[19] Wilson, D. & Conyers, M. (2013). Five Big Ideas for Effective Teaching: Connecting Mind, Brain, and Education Research to Classroom Practice. New York: Teachers College Press.
[20] Kuther, T. (2017). Lifespan Development: Lives in Context. Los Angeles: SAGE.
[21] Noggle, C. & Santos, E. (2011).
[22] Forsyth, J., Bachman, P., Mathalon, D., Roach, B., & Asarnow, R. (2015). Augmenting NMDA receptor signaling boosts experience-dependent neuroplasticity in the adult human brain. Proceedings of the National Academy of Sciences of the United States of America, 112(50),15331-15336. doi: 10.1073/pnas.1509262112
[23] Ibid.