Neuroplasticity 101

Until recently, scientists believed that brain development came to a halt during adulthood. But experts now know that our brains change constantly throughout our lives, forming new pathways to adjust to changes in our environment, actions, thinking and emotions.

What Is Neuroplasticity?

The brain creates new neural pathways and modifies existing ones in response to behavioral, environmental, and neural changes. 11 This process of neuroplasticity, also known as brain plasticity, continues throughout our lives, involves many processes and is influenced by new experiences. 22

Until recently, scientists believed that brain development came to a halt during adulthood. But researchers now know that our brains change constantly throughout our lives, forming new pathways to adjust to our environment and actions. 33 For example, neuroplasticity allows the brain to compensate for injury and disease. 44

Understanding how brain plasticity works can help us attain our own cognitive goals as well as improve the ways experts treat and support people with neurological and behavioral health problems.

How Do Our Brains Change?

Neuroplasticity would not be possible without the malleable traits of neurons. Neurons are what cause the brain to change and the entire body to function effectively. Neurons are the longest-living cells in our bodies and are responsible for carrying information throughout the brain and then on to the muscles and organs of the body. 56

Our brains have the extraordinary capacity to change both structurally and functionally. Structural plasticity involves our brains changing its physical structure as we learn new things or form new memories. Functional plasticity is the brain’s ability to move functions from a damaged area of the brain to other undamaged areas. 67

How Do Neurons Communicate?

A neuron generates electrical charges as it signals from other neurons. 78 Synapses, the tiny gaps where chemicals called neurotransmitters are released to transfer information from one cell to another, must be reinforced to remain active. 89910 The more synaptic pathways are used, the stronger the communication between neurons. 10111112

As we adapt to new environments, our brains dispose of unused or unnecessary neural connections while strengthening and preserving those that are used frequently. This activity is called synaptic pruning1213 For the brain to operate efficiently, synaptic pruning must maintain a proper balance. 1314 Researchers suggest that imbalanced brain pruning could be linked to some psychiatric and neurodegenerative issues. If not enough pruning occurs, the brain remains hyperconnected, which studies observe occurs in many cases of Schizophrenia and autism. Conversely, too much pruning disrupts communication between neurons, an abnormality found in Alzheimer’s disease. 1415

How Do Neurons Grow and Repair Themselves?

The human brain has billions of neurons, some of which can than live more 100 years in humans. 15161617 Unused neurons grow weak and die through a process called apoptosis, but can be regenerated by neurogenesis, the creation of new brain cells. 1718 With the support of other types of brain cells called glial, neurons can constantly repair, remodel and regenerate themselves. 1819

How Can You Rewire Your Brain?

Early childhood is the most critical time for learning. Though brain plasticity happens throughout our lives, children have a greater ability to learn and retain information. 1920 At birth, infants have approximately 2,500 synapses in the brain. From infancy to age 3, a child’s brain produces 15,000 synapses. 2021 Throughout adolescence, neurons weaken, reducing synapses by 50%. 2122

How can we build and maintain those connections that are relevant during early childhood and even later into adulthood? Neuroplasticity involves a “fire together, wire together” principle: If certain neurons keep firing at the same time, eventually they’ll develop a physical connection and become physically associated. This experience-dependent plasticity means if you practice something consistently, such as meditating, exercising or learning how to play an instrument, you’re likely to alter your brain to associate the relevant parts of its structure. Whether you are a child, adolescent or older adult, actions and thoughts (both positive and negative) that you repeat can form new neural pathways.

At the BrainFutures conference, Dr. Bruce Wexler, Professor Emeritus of Psychiatry and Senior Research Scientist at Yale School of Medicine, discussed the principles of neuroplasticity. Watch video below.



[1] Demarin, Vida & Morovic, Sandra & Béné, Raphael. (2014). Neuroplasticity. Periodicum Biologorum. 116. 209-211.
[2] Ibid.

[3] Neuroplasticity – HOPES Huntington’s Disease Information. (2016, November 05). Retrieved from
[4] Ibid.
[5] Brain Basics: The Life and Death of a Neuron. (n.d.). Retrieved August 15, 2018, from
[6] Ibid.
[7] Oberman, L., & Pascual-Leone, A. (2013). Changes in plasticity across the lifespan: Cause of disease and target for intervention. Progress in Brain Research, 207, 91–120.
[8] Pereda, A. E. (2014, April). Electrical synapses and their functional interactions with chemical synapses. Retrieved from
[9] Ibid.
[10] Sukel, K. (2011, March 15). The Synapse-A Primer. Retrieved from
[11] Ibid.
[12] Noggle, C. A., & Santos, E. (2011). Synaptic Pruning. Retrieved from
[13] Ibid.
[14] Afroz, S., Parato, J., Shen, H., & Smith, S. S. (2016, May 02). Synaptic pruning in the female hippocampus is triggered at puberty by extrasynaptic GABAA receptors on dendritic spines. Retrieved from
[15] Ibid.
[16] Sukel, K. (2011, March 15). The Synapse-A Primer. Retrieved from
[17] Alberts, B. (2002). Programmed Cell Death (Apoptosis). Retrieved August 15, 2018, from
[18] Ibid.
[19] What Happens to the Brain in Alzheimer’s Disease? (n.d.). Retrieved August 15, 2018, from
[20] Wilson, D. (2013). Five big ideas for effective teaching: Connecting mind, brain, and education research to classroom. NEW YORK: TEACHERS COLLEGE Press.
[21] Kuther, T. L. (2017). Lifespan development: Lives in context. Los Angeles: SAGE.
[22] Noggle, C. A., & Santos, E. (2011). Synaptic Pruning. Retrieved from
[23] Packham, C. (2015, December 08). Boosting experience-dependent neuroplasticity in adult brains. Retrieved from
[24] Ibid.